Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118
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Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118.
The mechanisms by which probiotic strains enhance the health of the host remain largely uncharacterized. Here we demonstrate that Lactobacillus salivarius UCC118, a recently sequenced and genetically tractable probiotic strain of human origin, produces a bacteriocin in vivo that can significantly protect mice against infection with the invasive foodborne pathogen Listeria monocytogenes. A stabl...
متن کاملBacteriocin production by Lactobacillus salivarius of animal origin.
Bacteriocins are secreted oligopeptides, proteins or protein complexes with antimicrobial activity against strains taxonomically related to the producer organism (2, 10). In recent years, numerous reports have been published on antimicrobial peptides or proteins produced by gram-positive bacteria, including lactic acid bacteria (LAB) (4, 7), and bacteriocins for lactobacilli from different envi...
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A recent comparative genomic hybridization study in our laboratory revealed considerable plasticity within the bacteriocin locus of gastrointestinal strains of Lactobacillus salivarius. Most notably, these analyses led to the identification of two novel unmodified bacteriocins, salivaricin L and salivaricin T, produced by the neonatal isolate L. salivarius DPC6488 with immunity, regulatory and ...
متن کاملHeterologous expression of BetL, a betaine uptake system, enhances the stress tolerance of Lactobacillus salivarius UCC118.
Given the increasing commercial and clinical relevance of probiotic cultures, improving the technological robustness of what are often process-sensitive cultures is an important biological goal. The nisin-controlled expression system was used to direct the heterologous expression of the listerial betaine uptake system BetL in the probiotic strain Lactobacillus salivarius UCC118. Following nisin...
متن کاملEffect of Lactobacillus salivarius Bacteriocin Abp118 on the Mouse and Pig Intestinal Microbiota
Lactobacilli are gram-positive bacteria that are a subdominant element in the human gastrointestinal microbiota, and which are commonly used in the food industry. Some lactobacilli are considered probiotic, and have been associated with health benefits. However, there is very little culture-independent information on how consumed probiotic microorganisms might affect the entire intestinal micro...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424
DOI: 10.1073/pnas.0700440104